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The psychedelic drug (or entheogen) lysergic acid diethylamide (LSD) was first synthesized on November 16, 1938, by the Swiss chemist Albert Hofmann in the Sandoz laboratories in Basel, Switzerland.

Albert Hofmann

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Major Psychedelic Substances & Types

  • Tryptamines: Psilocybin (mushrooms), DMT (dimethyltryptamine), Ayahuasca, 5-MeO-DMT, LSD (lysergamides).
  • Phenethylamines: Mescaline (found in peyote, San Pedro cactus), 2C-B, DOM.
  • Dissociatives (Hallucinogenic properties): Ketamine, PCP, DXM, Nitrous oxide.
  • Other/Plants: Salvinorin A, Ibogaine, Ayahuasca, Morning Glory seeds
  • Typical Duration of Effects (Oral)
  • LSD: 7–11 hours.
  • Mescaline: 10–14 hours.
  • Psilocybin: 5–6 hours.
  • DMT/5-MeO-DMT: 5–20 minutes (inhaled)
  • Commonly Used Terms
  • Entheogen: Used to describe these substances in a spiritual or shamanic context.
  • Designer Drugs: Synthetic variants such as 2C-B, 2C-I, or piperazines. 

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